DSC – Differential scanning calorimetry

Instrument details:
Type: DSC
Make: Shimadzu, Kyoto, Japan
Model No: DSC-60
Essential specification:
Measurement range: -140 to 600°C
Calorimetric measurement range ±150mW
Programmable heating/cooling rate +/- 0.1 to +/- 99.9°C /min ( 0.1°C /hr or 0.1°C /min step)
Programmable hold time 1min - 999hr (1min or 1hr step)
Atmosphere Nitrogen, inert gas, dry air gas flow
Software: Thermal analysis workstation TA-60WS
To weigh the sample, prepare an analytical balance which allows precise reading up to 0.01 mg.
Pans Al (Aluminium) crimp pans + lids and Al hermetic pans, limit pressure: 0.3 MPa
Working principle:
Differential Scanning Calorimetry (DSC) measures the temperatures and heat flows associated with transitions in materials as a function of time and temperature in a controlled atmosphere. A small amount of sample is heated, and if any kind of transition takes place during this process, it will lead to a slight difference between the sample and a reference sample temperature, i.e. differential scanning calorimetry measures the amount of energy (heat) absorbed or released by a sample as it is heated, cooled, or held at a constant temperature. The reference is an inert material such as alumina, or just an empty aluminium pan. The temperature of both the sample and reference are increased at a constant rate. Since the Differential Scanning Calorimeter is at constant pressure, heat flow is equivalent to enthalpy changes.
1. Nanomaterial characterization: Determine melting point of nanomaterial. 2. Examine the stability of the nanomaterial, as transitions or melting at low temperature is not desirable. 3. Evaluate the relative stability of different crystalline forms in order to avoid transitions between forms. 4. Evaluate crystallisation behaviour after heating – which might for instance lead to new polymorphic forms. 5. Compare batches: Differences in energies upon melting might be due to impurities or content of amorphous material and the results might be used for regulatory purposes.
Sample preparation at center/ self-prepared sample
Type of samples polymeric/metallic/peptide or protein
Type of solvent No solvent desired
Analysis Thermal stability
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